In the US, marijuana tops the charts for the most commonly used illicit drug. Studies show a rise in marijuana use over the past ten years, possibly linked to a declining view of its risks among the general public.
This plant, also known as cannabis, has over 120 chemical compounds called cannabinoids. The two most famous and studied ones are cannabidiol (CBD) and tetrahydrocannabinol (THC). THC creates the feeling of being high, while CBD doesn't have any intoxicating effects.
This blog dives into the specific genetic factors our DNA test analyzes (sleep, stress, anxiety, side effects, metabolism, and pain) to help you make informed decisions about managing your Cannabis intake.
1. Sleep
Many people use cannabis, both for medical reasons and recreation, to help them fall asleep. Studies show this is especially common:
- Roughly 70% of young casual users report using cannabis to sleep better.
- As many as 85% of medical cannabis users who use it for pain relief say it improves their sleep.
The body's natural sleep-wake cycle, known as the circadian rhythm, plays a key role in sleep regulation. Genetic variations can affect this rhythm, influencing whether you're a morning person or a night owl.
Scientists are still researching the long-term effects of cannabis on sleep. While it might help with occasional sleep problems, the long-term impacts remain unclear.
2. Stress
Our experience of stress isn't just about what happens to us in the moment. It's also shaped by our background, from how we were raised to our genes. These factors influence the chemicals in our body that control our stress response.
THC: A Balancing Act
Taking THC can be a double-edged sword for stress. Low doses may help you relax, while higher amounts can actually make you feel more stressed. This is why finding the right amount is key. Our test can help you determine the dosage level before you experience those adverse effects.
3. Anxiety
Feeling anxious? You're not alone. Many people experience anxiety, and while medications exist, they may not be the best fit for everyone. Some people are exploring natural approaches like cannabis, but finding the right solution can be challenging.
Science is uncovering connections between genes and anxiety. Our DNA test analyzes specific genes (BDNF, RGS2, and HTR1A) that have been linked to anxiety. This information could help you explore personalized strategies for managing anxiety, focusing on approaches that minimize discomfort.
4. Side Effects
While THC, CBD, and terpenes are well-known components of cannabis, there are over 100 other cannabinoids. Most of these are present in very low levels and have little effect on the body, but a few can impact the benefits and effects of using cannabis.
Possible side effects of using THC are memory impairment, dependence, and psychosis of Marijuana. Cannabis use can cause short-term memory impairments that typically disappear once use is discontinued.
Chronic marijuana use has been shown to down-regulate cannabinoid receptors in the brain. These receptors are what THC acts on to produce the high, and several genes are associated with cannabis dependence. Our DNA Test analyzes your CNR1 and CB1 genes (cannabinoid receptors) and determines whether you're at a higher risk for cannabis dependence.The vast majority of cannabis users do not experience psychosis as a side effect, but some do. Let us test your COMT gene, which is related to other psychotic disorders; your AKT1, which THC activates; and DRD2, a gene that codes for a dopamine receptor and has been implicated in the development of schizophrenia, to discover if you're at risk for developing psychosis.
5. Metabolism
Most people think of metabolism in the context of losing weight, and they aren't wrong, but there's more to it than that. Ever wonder how fast your body metabolizes Cannabis? Now you can.
Like most drugs, tetrahydrocannabinol (THC) is metabolized in the liver by CYP enzymes. Inhaling THC results in almost immediate effects, with THC being absorbed by the lungs and moving directly into the bloodstream.
Discover your unique bioavailability, meaning how much of the compound is actually able to be used by your body. When THC is orally ingested, it results in delayed effects since it has to travel through the digestive system and be absorbed by the small intestine. While this process takes only minutes when THC is inhaled, it can take several hours before effects can be felt following oral ingestion.
6. Pain
Every individual has a unique pain threshold. While some individuals may not have difficulty getting a tattoo, others may experience tears when they accidentally stubbing their toe. Though having a low pain tolerance may seem disadvantageous, it is important to note that pain is a crucial message that our bodies send to our brains.
Scientists are discovering that genetic factors influence our pain tolerance. The COMT gene codes an enzyme that breaks down catecholamines like dopamine, epinephrine, and norepinephrine. Studies have found that mutations within this gene can result in lower or higher-than-average pain sensitivity.
If you're using Cannabis to manage your pain, it's imperative to know the proper dosage, which can only be truly determined with a DNA Testing kit such as ours. Stop guessing how much THC you should consume and purchase your CUT-DNA test today to manage your pain correctly.
Final Thoughts:
Take control of your Cannabis journey, starting with understanding yourself. By unlocking the insights within your DNA, you can explore personalized strategies for maximizing the benefits of Marijuana and finding peace of mind during use. Our DNA test is a powerful tool to jumpstart your journey towards a confident, more comfortable you. Ready to begin? Get your DNA testing kit today!
Index:
- https://www.sleepfoundation.org/sleep-aids/cannabis-and-sleep/
- https://adai.uw.edu/pubs/pdf/2017mjanxiety.pdf
- https://drexel.edu/cannabis-research/research/research-highlights/2023/April/anxiety_cannabis_fact_sheet/